Following is a list of all the important universities offering wide-ranging study options to students in the state.

1. Anna University, Chennai
2. Bharath Institute of Higher Education & Research, Chennai
3. Dakshina Bharti Hindi Prachar Sabha, Chennai
4. Indian Institute of Technology Madras, Chennai
5. Dr. M.G.R. Educational and Research Institute, Chennai
6. Meenakshi Academy of Higher Education and Research, Chennai
7. Sathyabama Institute of Science and Technology, Chennai
8. Saveetha Institute of Medical and Technical Sciences, Chennai
9. Sri Ramachandra Medical College and Research Institute, Chennai
10. Tamil Nadu Dr. M G R Medical University, Chennai
11. Tamil Nadu Open University
12. Tamilnadu Veterinary and Animal Sciences University, Chennai
13. The Tamilnadu Dr. Ambedkar Law University, Chennai
14. University of Madras, Chennai
15. SRM University, Chennai
16. Alagappa University, Tamil Nadu
17. Amrita Vishwa Vidyapeetham, Tamil Nadu
18. Avinashlingam Institute for Home Science & Higher Education for Women, Tamil Nadu
19. Bharathidasan University, Tamil Nadu
20. Bharthiar University, Tamil Nadu
21. Dakshina Bharat Hindi Prachar Sabha, Tamil Nadu
22. Dr. M.G.R. Educational and Research Institute, Tamil Nadu
23. Gandhigram Rural Institute, Tamil Nadu
24. Karunya Institute of Technology and Sciences, Tamil Nadu
25. Madurai Kamaraj University, Tamil Nadu
26. Manonmaniam Sundaranar University, Tamil Nadu
27. Meenakshi Academy of Higher Education and Research, Tamil Nadu
28. Mother Teresa Women's University, Tamil Nadu
29. National Institute of Technology, Tamil Nadu
30. Periyar University, Tamil Nadu
31. Sathyabama Institute of Science and Technology, Tamil Nadu
32. Saveetha Institute of Medical and Technical Sciences, Tamil Nadu
33. Shanmugha Arts, Science, Technology & Research Academy, (SASTRA) Tamil Nadu
34. Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya, Tamil Nadu
35. Tamil Nadu Agricultural University, Tamil Nadu
36. Tamil Virtual University, Tamil Nadu
37. Tamil University, Tamil Nadu
38. Thiruvalluvar University, Tamil Nadu
39. Vellor Institute of Technology, Tamil Nadu
40. Vinayaka Mission's Research Foundation, Tamil Nadu